Category Archives: Alzheimers/Dementia

Evolution, Genetics, and Alzheimer’s

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Numerous trials have been run hoping to develop and validate drugs which would either slow, stop, or reverse the development of Alzheimer’s in humans. Yet over several decades none have succeeded. Almost all of these attempts have been based on the “amyloid hypothesis”, and consequently, some researchers have started looking in new directions.

One exciting such new direction involves mitochondrial DNA, which we inherit from our mothers, but not our fathers. This difference might account for the fact that people whose family history showed Alzheimer’s on their mother’s side were more likely to get Alzheimer’s than people whose family history only showed Alzheimer’s on the father’s side. So various mitochondrial diseases and failures could be genetically responsible for the development of Alzheimer’s in the brain.

It is widely regarded that most non-human primates do not exhibit Alzheimer’s, although they exhibit related symptoms and brain changes. The new study focused on the idea that thus, Alzheimer’s ought to have come about in human beings due to some evolutionarily recent change in our brains setting us apart from existing primate species. The study focused on one such change, the development of “retrotransposons”, or so-called “jumping genes”.

An excellent extended exposition of this work is available at
When copy-paste attacks: A possible answer to the mystery of Alzheimer’s disease

Another article about the work is
‘Jumping genes’ may set the stage for brain cell death in Alzheimer’s, other diseases

The research publication itself is at
The Alu neurodegeneration hypothesis: A primate-specific mechanism for neuronal transcription noise, mitochondrial dysfunction, and manifestation of neurodegenerative disease

Links to the articles and the research publication have been posted in Alzheimers > Risk Factors > Genetics.

Dementia: Hope & Despair for Patient & Caregiver

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Dasha Kiper has written a remarkable long piece about her year plus caring for a dementia patient. A shorter form was published as The deviousness of dementia while the longer version appeared as

Hope Is the Enemy: Caring for a patient suffering from dementia means coming to terms with the frustrating paradoxes of memory and language.

 
Links to both versions have been posted on Strong Brain in both
Alzheimers > Caregivers and Alzheimers > Coping Stories

Five New Links on Risk Factors for Alzheimer’s

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Five links were added in:

Alzheimers > Risk Factors

Here are the new links:
Type 2 diabetes linked with reduced cognitive function     …shown that people with diabetes have abnormal blood flow regulation in the brain, namely impaired ability to increase blood flow and deliver sugar and oxygen to the brain during episodes of increased mental activity

High Blood Sugar May Boost Alzheimer’s Risk     Insulin resistance can inhibit signaling between brain cells and affect memory…

Too much TV could raise the risk of Alzheimer’s, study suggests     It turns out that too much TV might damage your brain and also raise the risk of developing Alzheimer’s disease…

Survey: Risk Factors     The most important risk factors—age, family history and heredity—can’t be changed, but emerging evidence suggests there may be other factors we can influence.

Infection Inflicts A Persistent Decrease In IQ: A Danish Study With 180,000 Participants     A recent danish study … showed that infections can impair cognitive ability

Coffee On A Roll: 2 New Links

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We’ve added two more links reporting positive studies concerning coffee and cognitive function, in:

Alzheimers > Amelioration > Caffine

Here are the new links:

Coffee Consumption Habits Impact the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging     A new study… estimates the association between change or constant habits in coffee consumption and the incidence of mild cognitive impairment (MCI)…

Drinking Coffee May Delay Alzheimer’s Disease     Study Adds to Growing List of Health Benefits Associated With Coffee