Table of Anticholinergic Drugs

This table is the result of merging the lists in Anticholinergic Drugs to Avoid in the Elderly and List of Anticholinergic Drugs and Why Some of Them are Dangerous for Seniors. As the titles of the two source lists suggest, these drugs should be avoided by senior/elderly people, if at all possibe.

Many of the below drugs are found in over-the-counter (OTC) products or in combination with other medications (prescription or OTC).
If you have concerns about using anticholinergic drugs, check with your pharmacist, or possibly your doctor.
For example, multiple over-the-counter sleep medications contain diphenhydramine (Benadryl), a strong anticholinergic antihistamine.
The table below is not a complete list of anticholinergic drugs, but includes many of the most common ones to avoid, when possible.


Antihistamines, First-Generation
carbinoxamine Arbinoxa, Karbinal ER, Palgic
chlorpheniramine Actifed, Aller-Chlor, Allergy & Congestion Relief, Chlor-Trimeton, Codeprex, Efidac-24 Chlorpheniramine, etc.
clemastine Tavist Allergy
cyproheptadine Periactin
dexbrompheniramine Ala-Hist IR
dexchlorpheniramine Polaramine, Polaramine Repetabs
dimenhydrinate Dramamine
diphenhydramine*1(oral) Advil PM, Aleve PM, Allermax, Bayer PM, Benadryl, Excedrin PM, Nytol, Simply Sleep, Sominex, Tylenol PM, Unisom, etc.)
doxylamine Aldex AN, Unisom, Nytol Maximum Strength
hydroxyzine Atarax, Visteril
meclizine Antivert, Bonine, D-Vert, Dramamine Less Drowsy
promethazine Phenergan
pyrilamine an ingredient of combination cold medicines
triprolidine Histex, Zymine, Tripohist
    *1Use of diphenhydramine in acute allergic reactions may be appropriate; many OTC sleep agents have diphenhydramine as an active ingredient, be sure to check labels.
Antiparkinsonian Agents*2
benztropine Cogentin
    *2In general, these agents are not recommended for prevention of extrapyramidal symptoms with antipsychotics. In addition, more-effective agents are available for treatment of Parkinson disease, especially for older individuals.
Skeletal Muscle Relaxants
cyclobenzaprine Amrix, Fexmid, Flexeril
methocarbamol Robaxin
orphenadrine Norflex
disopyramide Norpace, Norpace CR
amitriptyline Elavil
clomipramine Anafranil
desipramine Norpramin
doxepin Adapin, Silenor, Sinequan
imipramine Tofranil, Tofranil-PM
nortriptyline Pamelor
paroxetine Brisdelle, Paxil, Paxil CR, Pexeva
protriptyline Vivactil
trimipramine Surmontil
Antimuscarinics (Urinary Incontinence)
darifenacin Enablex
fesoterodine Toviaz
flavoxate Urispas
oxybutynin Ditropan, Ditropan XL, Oxytrol
solifenacin Vesicare
tolterodine Detrol, Detrol LA
trospium Sanctura, Sanctura XR
chlorpromazine Thorazine
clozapine Clozaril, FazaClo, Versacloz
loxapine Loxitane
olanzapine Zyprexa, Zyprexa Relprevv, Zyprexa Zydis
trifluoperazine Stelazine
    *3Boxed warnings exist about the use of antipsychotics in the elderly with dementia. Antipsychotics are not approved for use in psychotic conditions related to dementia. Antipsychotics may increase the risk of death in older adults with dementia-related conditions.
atropine excludes ophthalmic [eye] agents
belladonna alkaloids
clidinium-chlordiazepoxide Librax
dicyclomine Bentyl
homatropine (excludes ophthalmic [eye] agents Tussigon)
hyoscyamine Anaspaz, Levbid, Levsin, NuLev
methscopolamine Pamine, Pamine Forte
scopolamine (excludes ophthalmic) Transderm Scop
prochlorperazine Compazine
promethazine Phenergan