Category Archives: Drugs

Alzheimer’s Mice Recovering

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A new drug, originally developed as a treatment for schizophrenia, appears to restore memories and neural connections in mice with models of Alzheimer’s disease, erasing evidence of Alzheimer’s synapse damage and memory loss. Of course, it’s a long way from repairing mouse models of Alzheimer’s to successfully handling human Alzheimer’s patients. But it’s a hopeful beginning.

Below is a link to an article about the study, as well as a link to the study itself:

Drug Restores Cells and Memories in Alzheimer’s: Mouse Study

Published research:
Silent Allosteric Modulation of mGluR5 Maintains Glutamate Signaling while Rescuing Alzheimer’s Mouse Phenotypes

Both links have been added to Alzheimers > Drugs

Category: Announcements, Drugs

Some Early Stage Drug Research

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Drug research relating to dementia and Alzheimer’s is ongoing. Below is a collection of relatively recent reports. All of the links have been added to Alzheimers > Treatment > Drugs


trazodone and dibenzoylmethane

From the articles:
A team of scientists who a few years ago identified a major pathway that leads to brain cell death in mice, have now found two drugs that block the pathway and prevent neurodegeneration. The drugs caused minimal side effects in the mice and one is already licensed for use in humans, so is ready for clinical trials.

Experts excited by brain ‘wonder-drug’
Scientists discover two repurposed drugs that arrest neurodegeneration in mice
Published research:
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice


Methylene blue

Drug Could Improve Short-term Memory, Study Says [06/28/2016]
Methylene Blue Shows Promise for Improving Short-Term Memory [June 28, 2016]
Published research:
Multimodal Randomized Functional MR Imaging of the Effects of Methylene Blue in the Human Brain [November 2016]


LMTX

Testing of new Alzheimer’s drug disappoints, but it’s not all bad news [July 27, 2016]
TauRx Alzheimer’s Drug LMTX Fails in Large Study Although Some Benefit Seen [July 27, 2016]


mefenamic acid

This Common Period Pain Medication Reverses Alzheimer’s Symptoms in Mice [16 Aug 2016]
Treatment option for Alzheimer’s disease possible [11 Aug 2016]
Alzheimer’s Disease: Period Pain Drug Cures Symptoms In Mice, New Research Shows [08/13/16]
Research publication:
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models [11 August 2016]


Category: Announcements, Drugs

Anti-Aging Effects From An Anti-Alzheimer’s Drug

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So far it’s only in mice, but a promising drug from a Salk Institute laboratory has shown the ability to not only reverse the effects of Alzheimer’s and memory loss, but to improve memory and other tests for cognition. In addition, older mice receiving the drug also displayed more robust motor movement, and based on gene expression monitoring, showed physiological aspects more similar to young mice, including increased energy metabolism, reduced brain inflammation and reduced levels of oxidized fatty acids in the brain. The laboratory hopes to being human trials next year.

Links to articles about the work, as well as the published study, have been posted in both Aging and Alzheimers > Treatment > Drugs:

Experimental Alzheimer’s Drug Shows Anti-Aging Effects

Experimental drug targeting Alzheimer’s disease shows anti-aging effects

Published study:
A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Category: Aging, Announcements, Drugs

More on Drugs for Alzheimers

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We’ve added four more links reporting on possible drugs relating to Alzheimers, in:

Alzheimers > Treatment > Drugs

Here are the new links:

Roche steps up work on two experimental Alzheimer’s drugs      …crenezumab would now move into late-stage Phase III …and … fresh clinical trials using higher doses of gantenerumab…

Blood pressure medication may lower Alzheimer’s risk     Researchers believe that anti-hypertensive drugs used to treat high blood pressure may be lowering patients’ risk of developing Alzheimer’s disease

Reduced Alzheimer’s risk linked to medicine for high blood pressure     …it’s possible that medications used to treat high blood pressure also lowers the risk for Alzheimer’s…

UPDATED: Eli Lilly offers evidence of twice-failed solanezumab’s impact on Alzheimer’s     Eli Lilly offered long-term evidence to show that its amyloid-busting drug solanezumab has a distinct impact on Alzheimer’s disease among early-stage patients…

Category: Announcements, Drugs