Distilled: Signs of the Onset of Dementia

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We’ve collected a number of web pages offering lists of symptoms of the onset of demetia, and have distilled out 18 of the signs. Keep in mind that the occasional and not long lasting appearance of one of these is most likely a sign of aging. However, regular occurrence of one or more of these signs is an indication that a visit to a physician or clinincal psychologist specializing in cognition is warrented.
The web links contributing to this list are collected at the bottom of this post.
Here are the 18 distilled signs:

1. Memory loss that disrupts daily life fairly often — not the occasional forgetting of a name or date that comes back later.
2. Challenges in planning or solving problems, or following recipes or keeping track of monthly bills.
3. Difficulty with numbers and/or handling money in shops.
4. Difficulty making familiar trips (walking or driving).
5. A failing sense of direction and spatial orientation, including wandering and getting lost.
6. Confusion about time or place.
7. Repeating questions after a short interval.
8. Vision problems, including difficulty reading, judging distance and determining color or contrast — not due to cataracts or other eye problems.
9. Problems with words in conversations or writing, including repeating themselves or stopping mid-conversation unable to continue; also failure to find the right word.
10. Difficulty following storylines.
11. Misplacing things (often in very unusal places) and losing the ability to retrace steps to find them.
12. Decreased or poor judgment, including mishandling money, and decreased attention to grooming and keeping clean.
13. Notable weight changes.
14. Withdrawal from work or social activities.
15. Apathy, or loss of spontaneity and sense of initiative.
16. Changes in mood and personality, including becoming confused, suspicious, depressed, fearful or anxious, or aggressive.
17. Lessening of ability to focus and concentrate.
18. Failure to recognize people they know.

Here are links to the web pages contributing:

10 Early Signs and Symptoms of Alzheimer’s
What are the early signs of dementia?
10 Early Symptoms of Dementia
Dementia – early signs
What Are the Signs of Alzheimer’s Disease?
Symptoms of dementia
Symptoms
Well, that was a weird moment’ and other signs of dementia family members should watch for [Possible paywall]
Dementia’s Signs May Come Early [Possible paywall]

All links have been added to Alzheimer’s > Diagnosis & Tests

More On Air Pollution & Dementia

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We previously put out a longish post about the effects of air pollution: Air Pollution: Shorter Life, More Dementia Risk, Worse Thinking. A London-based study from 2018 now extends those previous studies, showing that “We have found evidence of a positive association between residential levels of air pollution across London and being diagnosed with dementia, which is unexplained by known confounding factors.”

Here are two media articles on this study:
Is air pollution tied to higher dementia risk?
Air pollution linked to much greater risk of dementia
Here is a link to the study itself:
Are noise and air pollution related to the incidence of dementia? A cohort study in London, England

All links have been added to Alzheimer’s > Risk Factors.

Say Bye Bye To Supplements

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Americans spend over $30 billion each year on dietary supplements, basically vitamins, minerals and herbal products. Yet there has been little evidence of the values of these supplements for normally healthy people. Now there are accumulating studies which show that for normally healthy people, most all of these supplements provide no significant value, and in some cases may even do harm.

Here are two media articles on the most recent of these studies:
There’s even more evidence that taking supplements is a waste of money — and could be harmful to your health
Nutrients from food, not supplements, linked to lower risks of death, cancer
And here is a link to the study itself:
Association Among Dietary Supplement Use, Nutrient Intake, and Mortality Among U.S. Adults: A Cohort Study

Here are posts about supplements from the American Heart Association and Johns Hopkins doctors:
Vitamin Supplements: Hype or Help for Healthy Eating
Is There Really Any Benefit to Multivitamins?
This is a link to the original editorial by the Hopkins doctors:
Enough Is Enough: Stop Wasting Money on Vitamin and Mineral Supplements

As discussed in FDA: Stop Making False Claims For Supplements, the FDA recently sent out warning letters to supplement manufacturers telling them to stop claiming anti-Alzheimer’s benefits from their products. Because the FDA has limited ability to regulate the supplements industry, the situation has be come bizarre:
Nearly 800 dietary supplements contained unapproved drug ingredients, study finds
Original study:
Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings

All links have been added to Alzheimer’s > Amelioration/Prevention > Vitamins & Select Foods.

US Dementia & Death Rates Increasing

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Dementia continues to grow as a significant problem in the United States. The CDC forecasts that between 2014 and 2060, the percent of the U.S. population living with dementia will rise from 1.6% of the population (5 million people) in 2014 to approximately 3.3% (13.9 million people) in 2060. And the rate at which Americans are dying directly from dementia has more than doubled from 30.5 deaths per 100,000 people in 2000 to 66.7 per 100,000 in 2017. And the cost to the U.S. is staggering, approaching $300 billion per year.

Here are two media articles about the expected doubling of the percent of U.S. persons living with dementia:
Rate of Americans living with Alzheimer’s expected to double by 2060
World Alzheimer’s Day: Why US Dementia Rates Will Likely Double By 2060
Here is the published CDC report:
Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

Here are two media articles about the more than double increase in U.S. deaths directly due to dementia:
Deaths from dementia have more than doubled in US, report says
U.S. Dementia-Linked Death Rate More Than Doubles
Here is the CDC report:
Dementia Mortality in the United States, 2000–2017

Here are two media articles on the costs of Alzheimer’s disease to the U.S. health care system:

Alzheimer’s costs Americans $277 billion a year — and rising

Alzheimer’s: The Most Expensive Disease in America

All links have been added to Alzheimer’s > Epidemiology.

Best To Avoid Over-Processed Foods

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Processed foods typically contain lots of additives, especially sodium (salt) and sugars. Of course, to a certain extent, that’s why they are so tasty. But the more over-processed foods are definitely not so healthy for you. Two recent studies drive that home. The first shows that the more processed food you consume, the greater your chances of early death due to heart disease, cancer, and other causes. The second (small-scale, but a randomized controlled trial) showed that eating highly processed foods tends to lead one to consume more calories.

Below we present two groups of media articles and links for these two studies. Then at the end of this post, we present a group of articles discussing what are and are not highly processed foods.

Over-/Ultra-processed food consumption can lead to early death.


The study relating ultra-processed food consumption to early death involved 44,551 French adults age 45 and older, for two years, with average age 57; almost 73% of the participants were women. Each subject provided 24-hour dietary records every six months, and also completed questionnaires about their health, physical activities and sociodemographics. Using these records, the researchers calculated each participant’s overall dietary intake and consumption of ultraprocessed foods, finding that ultraprocessed foods accounted for more than 14% of the weight of total food consumed and about 29% of total calories. For every 10% increase in the proportion of ultraprocessed foods in a subject’s diet, the risk for all-causes death increased by 14%.

Here are links to media articles about the study:
Avoiding ‘ultraprocessed’ foods may increase lifespan, study says
Consuming Ultraprocessed Food Tied to Higher Mortality
Study: ‘Ultraprocessed’ Foods Are Accelerating Your Risk Of Early Death
New French study explores risks of ultra-processed food

Here are links to the research article abstract:
Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France
Association Between Ultraprocessed Food Consumption and Risk of Mortality Among Middle-aged Adults in France.

Ultra-processed food diets bulk you up.


Twenty experimental subjects stayed at an NIH center and had meals provided to them. For 14 days they had highly ultra-processed meals, and for 14 days they ate minimally processed foods. The basic meals contained the same amount of sugars, fiber, fat and carbohydrates, but the participants were allowed to eat as much as they liked, by taking extra or fewer helpings. The participants all exercised about the same amount each day throughout the study.

When on the ultra-processed diet, people ate faster, yet consumed about 500 calories more per day (by taking extra helpings) than they did while on the unprocessed diet; this increase in calories was due to higher quantities of carbohydrates and fat but not protein. Consequently, when on the ultra-processed diet, participants gained weight — on average, about 2 pounds. While on the diet of unprocessed foods, they lost an equal amount of weight. The study authors concluded that the ultraprocessed foods caused people to eat too many calories and gain weight.

Here are links to media articles about this study:
Overprocessed foods add 500 calories to your diet every day, causing weight gain
Processed foods lead to weight gain, but it’s about more than calories
New study says processed foods make us crave more calories
Processed food leads people to eat more and put on weight, study finds
First-of-its-kind trial finds processed food causes overeating, but researchers not sure why

Here is the research article:
Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient Randomized Controlled Trial of Ad Libitum Food Intake

What are ultra-processed foods?


Here are a number of media articles and articles from health-related organizations, all discussing what should count as “ultra-processed” foods, and how to diminish their proportion in one’s diet:

Eating processed foods
Can Processed Foods Be Part of a Healthy Diet
‘Detox’ from overly processed foods: Why and how to cut back
What is ultra-processed food and how can you eat less of it?
Processed Foods: 5 Reasons to Avoid Them
Not all processed foods are unhealthy

All links have been added to Health > Diet.

Category: Diet, Health

Sleep & Alzheimer’s

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Recent research demonstrates a good reason to sleep deeply: the slow and steady brain (and cardiopulmonary) activity associated with deep non-REM sleep are best for the function of the glymphatic system, the brain’s unique process of removing waste. That waste includes toxic proteins like beta amyloid and tau which are associated with Alzheimer’s.

Here are two media articles on the work:
Not all sleep is equal when it comes to cleaning the brain
Study: Deep Sleep Best for Brain ‘Cleaning,’ Emphasizes Link Between Sleep and Alzheimer’s

The research article is published at [paywall]: Science 22 Feb 2019: Vol. 363, Issue 6429, pp. 831-832.

The links have been added to Alzheimer’s > Neurology & Neuroplasticity.

Sounds Like SF: Brain Zaps Boost Memory

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Short-term (“working”) memory is crucial for a range of cognitive activities, ranging from reading to counting and more. As we, say, read a sentence, groups of brain neurons fire in coordinated ways to create brain waves to hold words in working memory as long as we need them to comprehend the sentence. As we age, these coordinated brain waves begin to fall out of sync, causing short-term memory to falter.

Recently published research demonstrated that applying jolts of weak electrical current can synchronize waves in the prefrontal and temporal cortex—two brain areas critical for cognition. The experimental subjects were 42 healthy people in their 60s and 70s. On associated visual recognition tests, the subjects improved their test performance for about an hour. A control group had current applied to different brain areas and did not show any test improvement. Interestingly, applying current to produce “chatter” in the brains of young people in their 20’s reduced their test performance.

Below are four media articles on the work:
Zapping elderly brains with electricity improves short-term memory—for almost an hour
Scientists reverse memory decline using electrical pulses
Could Transcranial Brain Stimulation Help Sharpen Memory?
Brain zaps boost memory in people over 60

Here is the Boston University press release on the work:
As Memories Fade, Can We Supercharge Them Back to Life?

Here is a link to the research article:
Working memory revived in older adults by synchronizing rhythmic brain circuits

All links have been added to Neuro-Psych.

Category: Neuro-Psych

Sniffing For Alzheimer’s

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The idea of being able to utilize an inexpensive “scratch & sniff” test such as described in Smelling Alzheimer’s & Brain Injury? to obtain early warnings of possible Alzheimer’s onset is certainly intriguing, and work is ongoing. Most recently, a study reported a correlation between development of poor sense of smell and a notably higher incidence of death within 10 years. The mechanism(s) and meaning(s) remain unclear.

Here are two media articles on the work:
Routine sense of smell tests could be used to spot signs of dementia
Poor sense of smell associated with nearly 50 percent higher risk for death in 10 years

Here is the research publication Summary for Patients:
Poor Sense of Smell and Risk for Death in Older Adults

Here are interesting overviews from 2017 and 2018:
Smell Test May Sniff Out Oncoming Parkinson’s and Alzheimer’s
Can a Smell Test Sniff Out Alzheimer’s Disease?

Here are media articles on several smell-related research reports from 2017:
Sniffing out dementia with a simple smell test
Alzheimer’s could be diagnosed early with sniff tests
Sniffing out dementia with a simple smell test

All links have been added to Alzheimer’s > Diagnosis & Tests.

World Health Organization (WHO) Dementia Recommendations

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The WHO recently released it’s first recommendations regarding prevention or delay of dementia. They include: getting regular physical exercise, not using tobacco, drinking less alcohol, maintaining healthy blood pressure, cholesterol, and blood sugar levels, and eating a healthy diet — particularly a Mediterranean diet. WHO also warned against taking dietary supplements such as vitamins B and E in an effort to combat cognitive decline and dementia.
Additionally, “An essential element of every national dementia plan is support for carers of people with dementia,” said Dr Dévora Kestel, Director of the Department of Mental Health and Substance Abuse at WHO. “Dementia carers are very often family members who need to make considerable adjustments to their family and professional lives to care for their loved ones.

Here are five media articles about the WHO report, including two covering expert reactions to the report:
Eat well, exercise more: New global guidelines to reduce risk of dementia
6 Ways To Reduce Your Risk Of Dementia, According To A New Report
WHO issues first advice on dementia: exercise and don’t smoke
expert reaction to WHO Guidelines on risk reduction of cognitive decline and dementia
How to cut your dementia risk, according to experts

Here are two WHO press releases, together with a set of WHO links on management of dementia:
Adopting a healthy lifestyle helps reduce the risk of dementia
WHO guidelines on risk reduction of cognitive decline and dementia
Evidence-based recommendations for management of dementia in non-specialized health settings

All links have been added to Alzheimer’s > Amelioration/Prevention.

FDA: Stop Making False Claims For Supplements

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The US FDA has sent warning letters to 17 manufacturers of supplements, warning them to cease making unsubstantiated claims that their products will prevent, treat or cure Alzheimer’s disease. These companies are illegally selling over 58 products which are unapproved new drugs and/or misbranded drugs.

Here are three media articles about the action:
FDA sends warning letters to 17 companies for ‘illegally selling’ products claiming to treat Alzheimer’s
FDA targets illegally marketed dietary supplements
Supplement Makers Touting Cures for Alzheimer’s and Other Diseases Get F.D.A. Warning

Here is the FDA press release:
FDA takes action against 17 companies for illegally selling products claiming to treat Alzheimer’s disease

All links have been added to
Alzheimers > Amelioration/Prevention > Vitamins & Select Foods.